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Immediate-early, early, and late responses to DNA double stranded breaks
SR Kieffer, NF Lowndes - Frontiers in Genetics, 2022 - frontiersin.org
Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
[HTML][HTML] Acetylation in pathogenesis: revealing emerging mechanisms and therapeutic prospects
N Jiang, W Li, S Jiang, M **e, R Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Protein acetylation modifications play a central and pivotal role in a myriad of biological
processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and …
processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and …
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …
Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding
Heterochromatin protein 1α (HP1α) is a crucial element of chromatin organization. It has
been proposed that HP1α functions through liquid-liquid phase separation (LLPS), which …
been proposed that HP1α functions through liquid-liquid phase separation (LLPS), which …
HP1-driven phase separation recapitulates the thermodynamics and kinetics of heterochromatin condensate formation
The spatial segregation of pericentromeric heterochromatin (PCH) into distinct, membrane-
less nuclear compartments involves the binding of Heterochromatin Protein 1 (HP1) to …
less nuclear compartments involves the binding of Heterochromatin Protein 1 (HP1) to …
Multimodal interactions drive chromatin phase separation and compaction
T Ukmar-Godec, MS Cima-Omori, Z Yerkesh… - Proceedings of the …, 2023 - pnas.org
Gene silencing is intimately connected to DNA condensation and the formation of
transcriptionally inactive heterochromatin by Heterochromatin Protein 1α (HP1α). Because …
transcriptionally inactive heterochromatin by Heterochromatin Protein 1α (HP1α). Because …
Coarse-grained models to study protein–DNA interactions and liquid–liquid phase separation
Recent advances in coarse-grained (CG) computational models for DNA have enabled
molecular-level insights into the behavior of DNA in complex multiscale systems. However …
molecular-level insights into the behavior of DNA in complex multiscale systems. However …
ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers
R Yelagandula, K Stecher, M Novatchkova… - Nature cell …, 2023 - nature.com
ZNF462 haploinsufficiency is linked to Weiss–Kruszka syndrome, a genetic disorder
characterized by neurodevelopmental defects, including autism. Though conserved in …
characterized by neurodevelopmental defects, including autism. Though conserved in …
[HTML][HTML] Molecular mechanisms for the regulation of nuclear membrane integrity
The nuclear membrane serves a critical role in protecting the contents of the nucleus and
facilitating material and signal exchange between the nucleus and cytoplasm. While …
facilitating material and signal exchange between the nucleus and cytoplasm. While …
[HTML][HTML] Uncoupling the distinct functions of HP1 proteins during heterochromatin establishment and maintenance
Summary H3K9 methylation (H3K9me) marks transcriptionally silent genomic regions called
heterochromatin. HP1 proteins are required to establish and maintain heterochromatin. HP1 …
heterochromatin. HP1 proteins are required to establish and maintain heterochromatin. HP1 …