The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

The members of the organic anion transporting polypeptide superfamily (OATPs) are
classified within the SLCO solute carrier family. All functionally well characterized members …

Mycotoxins are fungal secondary metabolites contaminating food and causing toxicity to
animals and humans. Among the various mycotoxins found in crops used for food and feed …

The pharmaceutical industry remains solely reliant on synthetic chemistry methodology to
prepare compounds for small‐molecule drug discovery programmes. The importance of the …

Ageing is characterized by a progressive decline in the functional reserve of multiple organs
and systems, which can influence drug disposition. In addition, comorbidity and …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Because they mainly do not involve chemical changes, membrane transporters have been a
Cinderella subject in the biotechnology of small molecule production, but this is a serious …

Platinum-based drugs are among the most active anticancer agents and are successfully
used in a wide variety of human malignancies. However, acquired and/or intrinsic resistance …

Background The term 'metabolome'was introduced to the scientific literature in September
1998. Aim and key scientific concepts of the review To mark its 18-year-old 'coming of age' …