Mycobacterium tuberculosis infection of host cells in space and time
Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …
The granuloma in tuberculosis: dynamics of a host–pathogen collusion
A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …
Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate
MP Hall, J Unch, BF Binkowski, MP Valley… - ACS chemical …, 2012 - ACS Publications
Bioluminescence methodologies have been extraordinarily useful due to their high
sensitivity, broad dynamic range, and operational simplicity. These capabilities have been …
sensitivity, broad dynamic range, and operational simplicity. These capabilities have been …
Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in …
Abstract Development of an effective tuberculosis (TB) vaccine has suffered from an
incomplete understanding of the correlates of protection against Mycobacterium tuberculosis …
incomplete understanding of the correlates of protection against Mycobacterium tuberculosis …
Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis
Infections caused by antibiotic-resistant bacteria are a rising public health threat and make
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …
Design of a broad-range bacteriophage cocktail that reduces Pseudomonas aeruginosa biofilms and treats acute infections in two animal models
The alarming diffusion of multidrug-resistant (MDR) bacterial strains requires investigations
on nonantibiotic therapies. Among such therapies, the use of bacteriophages (phages) as …
on nonantibiotic therapies. Among such therapies, the use of bacteriophages (phages) as …
Seeing (and using) the light: recent developments in bioluminescence technology
AC Love, JA Prescher - Cell Chemical Biology, 2020 - cell.com
Bioluminescence has long been used to image biological processes in vivo. This technology
features luciferase enzymes and luciferin small molecules that produce visible light …
features luciferase enzymes and luciferin small molecules that produce visible light …
Zebrafish embryos and larvae: a new generation of disease models and drug screens
Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …
Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape
In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-
binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L, D …
binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L, D …
NAD (H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis
HT Pacl, KC Chinta, VP Reddy, S Nadeem… - Nature …, 2023 - nature.com
Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an
unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably …
unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably …