The availability of the first molecular clone of the hepatitis C virus (HCV) genome allowed
the identification and biochemical characterization of two viral enzymes that are targets for …

Great progress has been made over the past years in elucidating the structure and function
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …

Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million
chronic infections worldwide. Although highly potent direct-acting antiviral drugs to treat …

One of the most exciting developments in antiviral research has been the discovery of the
direct-acting antivirals (DAAs) that effectively cure chronic hepatitis C virus (HCV) infections …

Miravirsen is a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense
oligonucleotide targeting the liver-specific microRNA-122 (miR-122). Miravirsen …

Hepatitis C virus (HCV) is a positive sense, single-stranded RNA virus in the Flaviviridae
family. It causes acute hepatitis with a high propensity for chronic infection. Chronic HCV …

Low micromolar, non-cytotoxic concentrations of cyclosporin A (CsA) strongly affected the
replication of severe acute respiratory syndrome coronavirus (SARS-CoV), human …

Resolution of the three-dimensional structures of several hepatitis C virus (HCV) proteins,
together with the development of replicative cell culture systems, has led to the identification …

During the late 1990s and early 2000s, major advances were made in the treatment of
patients with chronic hepatitis C virus (HCV) infection. Interferon, combination interferon plus …

Coronaviruses infect a variety of mammalian and avian species and cause serious diseases
in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS) …