Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Small-molecule fluorescent probes for binding-and activity-based sensing of redox-active biological metals

K Grover, A Koblova, AT Pezacki, CJ Chang… - Chemical …, 2024 - ACS Publications
Although transition metals constitute less than 0.1% of the total mass within a human body,
they have a substantial impact on fundamental biological processes across all kingdoms of …

Recent advances in multifunctional fluorescent probes for viscosity and analytes

X Yang, D Zhang, Y Ye, Y Zhao - Coordination Chemistry Reviews, 2022 - Elsevier
Viscosity has become increasingly important in biological systems, especially as a major
factor in the process of diffusion control. The abnormality of viscosity is closely related to the …

Caveat fluorophore: an insiders' guide to small-molecule fluorescent labels

JB Grimm, LD Lavis - Nature Methods, 2022 - nature.com
The last three decades have brought a revolution in fluorescence microscopy. The
development of new microscopes, fluorescent labels and analysis techniques has pushed …

Hemicyanine‐based near‐infrared activatable probes for imaging and diagnosis of diseases

Z Zeng, SS Liew, X Wei, K Pu - … Chemie International Edition, 2021 - Wiley Online Library
Molecular activatable probes with near‐infrared (NIR) fluorescence play a critical role in in
vivo imaging of biomarkers for drug screening and disease diagnosis. With structural …

Fluorescent small organic probes for biosensing

X Tian, LC Murfin, L Wu, SE Lewis, TD James - Chemical science, 2021 - pubs.rsc.org
Small-molecule based fluorescent probes are increasingly important for the detection and
imaging of biological signaling molecules due to their simplicity, high selectivity and …

Synthetic ratiometric fluorescent probes for detection of ions

SH Park, N Kwon, JH Lee, J Yoon, I Shin - Chemical Society Reviews, 2020 - pubs.rsc.org
Metal cations and anions are essential for versatile physiological processes. Dysregulation
of specific ion levels in living organisms is known to have an adverse effect on normal …

Activatable molecular probes for second near‐infrared fluorescence, chemiluminescence, and photoacoustic imaging

J Huang, K Pu - Angewandte Chemie International Edition, 2020 - Wiley Online Library
Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering
and autofluorescence in biological tissue between 650–900 nm, conventional optical …

Dual-locked spectroscopic probes for sensing and therapy

L Wu, J Huang, K Pu, TD James - Nature Reviews Chemistry, 2021 - nature.com
Optical imaging probes allow us to detect and uncover the physiological and pathological
functions of an analyte of interest at the molecular level in a non-invasive, longitudinal …

Room‐temperature phosphorescence resonance energy transfer for construction of near‐infrared afterglow imaging agents

Q Dang, Y Jiang, J Wang, J Wang, Q Zhang… - Advanced …, 2020 - Wiley Online Library
Afterglow imaging that detects photons after cessation of optical excitation avoids tissue
autofluorescence and thus possesses higher sensitivity than traditional fluorescence …