How life emerged from simple non‐life chemicals on the ancient Earth is one of the greatest
mysteries in biology. The gene expression system of extant life is based on the …

How did specific useful protein sequences arise from simpler molecules at the origin of life?
This seemingly needle-in-a-haystack problem has remarkably close resemblance to the old …

Thiyl radicals are exceptionally interesting reactive sulfur species (RSS), but rather rarely
considered in a biological or medical context. We here review the reactivity of protein thiyl …

In CASP15, 87 predictors submitted around 11 000 models on 41 assembly targets. The
community demonstrated exceptional performance in overall fold and interface contact …

Peptide-RNA coacervates can result in the concentration and compartmentalization of
simple biopolymers. Given their primordial relevance, peptide-RNA coacervates may have …

Numerous molecular machines are required to drive the central dogma of molecular biology.
However, the means by which these numerous proteins emerged in the early evolutionary …

Why life encodes specific proteinogenic amino acids remains an unsolved problem, but a
non-enzymatic synthesis that recapitulates biology's universal strategy of stepwise N-to-C …

The emergence of proteins and their interactions with RNAs were a key step in the origin
and early evolution of life. The abiotic synthesis of peptides has been limited in short amino …

Accretion and the resulting increase in local concentration is a widespread mechanism in
biology to enhance biomolecular functions (for example, in liquid-liquid demixing phases) …

Valosin-containing protein (VCP) plays a crucial role in various cellular processes, yet the
molecular mechanisms and structural dynamics of its double-psi β-barrel (DPBB) domain …