Tau and tauopathies

T Arendt, JT Stieler, M Holzer - Brain research bulletin, 2016‏ - Elsevier
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

The neuropathology of chronic traumatic encephalopathy

AC McKee, TD Stein, PT Kiernan, VE Alvarez - Brain pathology, 2015‏ - Wiley Online Library
Repetitive brain trauma is associated with a progressive neurological deterioration, now
termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in …

Tau pathology and neurodegeneration

MG Spillantini, M Goedert - The Lancet Neurology, 2013‏ - thelancet.com
The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and
filamentous tau protein is at the centre of many human neurodegenerative diseases …

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

H Zempel, E Mandelkow - Trends in neurosciences, 2014‏ - cell.com
Tau is a microtubule-associated-protein that is sorted into neuronal axons in physiological
conditions. In Alzheimer disease (AD) and other tauopathies, Tau sorting mechanisms fail …

“Don't Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies

Y **a, S Prokop, BI Giasson - Molecular neurodegeneration, 2021‏ - Springer
Phosphorylation is one of the most prevalent post-translational modifications found in
aggregated tau isolated from Alzheimer's disease (AD) patient brains. In tauopathies like …

Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment

H Le Freche, J Brouillette… - Survey of …, 2012‏ - journals.lww.com
There is increasing interest in the role that anesthetic agents might play in the etiology of
postoperative cognitive dysfunction (POCD). Recent animal studies suggest that acute …

DHA ameliorates cognitive ability, reduces amyloid deposition, and nerve fiber production in Alzheimer's disease

M **ao, W **ang, Y Chen, N Peng, X Du, S Lu… - Frontiers in …, 2022‏ - frontiersin.org
Background The etiology of Alzheimer's disease (AD) is very complex. Docosahexaenoic
acid (DHA) is important in cognitive ability and nervous system development. A limited …

Physical resilience: not simply the opposite of frailty

HE Whitson, HJ Cohen, K Schmader… - Journal of the …, 2018‏ - pmc.ncbi.nlm.nih.gov
Physical resilience, which we define as one's ability to withstand or recover from functional
decline following acute and/or chronic health stressors1, is a construct that resonates with …

Oligomer formation of tau protein hyperphosphorylated in cells

K Tepper, J Biernat, S Kumar, S Wegmann… - Journal of Biological …, 2014‏ - jbc.org
Abnormal phosphorylation (" hyperphosphorylation") and aggregation of Tau protein are
hallmarks of Alzheimer disease and other tauopathies, but their causative connection is still …

The enigma of tau protein aggregation: mechanistic insights and future challenges

H Zheng, H Sun, Q Cai, HC Tai - International Journal of Molecular …, 2024‏ - mdpi.com
Tau protein misfolding and aggregation are pathological hallmarks of Alzheimer's disease
and over twenty neurodegenerative disorders. However, the molecular mechanisms of tau …