[HTML][HTML] Advances in animal models of prenatal opioid exposure

JR Ferrante, JA Blendy - Trends in Neurosciences, 2024 - cell.com
Neonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The
complexity of in utero opioid exposure in clinical studies makes it difficult to investigate …

Early brain activity: translations between bedside and laboratory

HJ Luhmann, PO Kanold, Z Molnár… - Progress in neurobiology, 2022 - Elsevier
Neural activity is both a driver of brain development and a readout of developmental
processes. Changes in neuronal activity are therefore both the cause and consequence of …

Opioid-induced dysbiosis of maternal gut microbiota during gestation alters offspring gut microbiota and pain sensitivity

YF Abu, S Singh, J Tao, I Chupikova, P Singh… - Gut …, 2024 - Taylor & Francis
There has been a rapid increase in neonates born with a history of prenatal opioid
exposure. How prenatal opioid exposure affects pain sensitivity in offspring is of interest, as …

Unique pharmacology, brain dysfunction, and therapeutic advancements for fentanyl misuse and abuse

Y Han, L Cao, K Yuan, J Shi, W Yan, L Lu - Neuroscience Bulletin, 2022 - Springer
Fentanyl is a fully synthetic opioid with analgesic and anesthetic properties. It has become a
primary driver of the deadliest opioid crisis in the United States and elsewhere …

Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development

SC Simmons, GG Grecco, BK Atwood, FS Nugent - Neuropharmacology, 2023 - Elsevier
In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …

Trajectories of brain and behaviour development in the womb, at birth and through infancy

S Meredith Weiss, E Aydin, S Lloyd-Fox… - Nature Human …, 2024 - nature.com
Birth is often seen as the starting point for studying effects of the environment on human
development, with much research focused on the capacities of young infants. However …

Inhibition of post-lanosterol biosynthesis by fentanyl: potential implications for Fetal Fentanyl Syndrome (FFS)

Z Korade, AC Anderson, K Sharma, KA Tallman… - Molecular …, 2024 - nature.com
A recent study discovered a novel, complex developmental disability syndrome, most likely
caused by maternal fentanyl use disorder. This Fetal Fentanyl Syndrome (FFS) is …

[HTML][HTML] Fentanyl induces autism-like behaviours in mice by hypermethylation of the glutamate receptor gene Grin2b

Z Sheng, Q Liu, C Cheng, M Li, J Barash… - British Journal of …, 2022 - Elsevier
Background Environmental factors contribute to autism spectrum disorder. Fentanyl, one of
the most widely used opioid analgesics in anaesthesia, can induce neurotoxicity, but its role …

Alterations of brain microstructures in a mouse model of prenatal opioid exposure detected by diffusion MRI

GG Grecco, SS Shahid, BK Atwood, YC Wu - Scientific reports, 2022 - nature.com
Growing opioid use among pregnant women is fueling a crisis of infants born with prenatal
opioid exposure. A large body of research has been devoted to studying the management of …

Opioid, methamphetamine, and polysubstance use: Perinatal outcomes for the mother and infant

TA Wouldes, BM Lester - Frontiers in Pediatrics, 2023 - frontiersin.org
The escalation in opioid pain relief (OPR) medications, heroin and fentanyl, has led to an
increased use during pregnancy and a public health crisis. Methamphetamine use in …