Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases
The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …
[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
Global signatures of protein and mRNA expression levels
Cellular states are determined by differential expression of the cell's proteins. The
relationship between protein and mRNA expression levels informs about the combined …
relationship between protein and mRNA expression levels informs about the combined …
Role of eIF2α kinases in translational control and adaptation to cellular stress
RC Wek - Cold Spring Harbor perspectives in biology, 2018 - cshperspectives.cshlp.org
A central mechanism regulating translation initiation in response to environmental stress
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …
Overview and findings from the rush Memory and Aging Project
DA Bennett, JA Schneider… - Current Alzheimer …, 2012 - ingentaconnect.com
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort
study of common chronic conditions of aging with an emphasis on decline in cognitive and …
study of common chronic conditions of aging with an emphasis on decline in cognitive and …
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …
An overview of APP processing enzymes and products
The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …
Protein aggregation diseases: pathogenicity and therapeutic perspectives
A Aguzzi, T O'connor - Nature reviews Drug discovery, 2010 - nature.com
A growing number of diseases seem to be associated with inappropriate deposition of
protein aggregates. Some of these diseases—such as Alzheimer's disease and systemic …
protein aggregates. Some of these diseases—such as Alzheimer's disease and systemic …
The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review
N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …
Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
T Ma, MA Trinh, AJ Wexler, C Bourbon, E Gatti… - Nature …, 2013 - nature.com
Expression of long-lasting synaptic plasticity and long-term memory requires protein
synthesis, which can be repressed by phosphorylation of eukaryotic initiation factor 2 α …
synthesis, which can be repressed by phosphorylation of eukaryotic initiation factor 2 α …