How COVID-19 has fundamentally changed clinical research in global health

JJH Park, R Mogg, GE Smith… - The Lancet Global …, 2021 - thelancet.com
COVID-19 has had negative repercussions on the entire global population. Despite there
being a common goal that should have unified resources and efforts, there have been an …

COVID-19: characteristics and therapeutics

R Chilamakuri, S Agarwal - Cells, 2021 - mdpi.com
Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in
December 2019 is still haunting the entire human race and has affected not only the …

Multicenter interim guidance on use of antivirals for children with coronavirus disease 2019/severe acute respiratory syndrome coronavirus 2

K Chiotos, M Hayes, DW Kimberlin… - Journal of the …, 2021 - academic.oup.com
Background Although coronavirus disease 2019 (COVID-19) is a mild infection in most
children, a small proportion develop severe or critical illness. Data describing agents with …

Current strategies of antiviral drug discovery for COVID-19

M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …

BACPI: a bi-directional attention neural network for compound–protein interaction and binding affinity prediction

M Li, Z Lu, Y Wu, YH Li - Bioinformatics, 2022 - academic.oup.com
Motivation The identification of compound–protein interactions (CPIs) is an essential step in
the process of drug discovery. The experimental determination of CPIs is known for a large …

COVID-19, cytokines, inflammation, and spices: How are they related?

AB Kunnumakkara, V Rana, D Parama, K Banik… - Life sciences, 2021 - Elsevier
Background Cytokine storm is the exaggerated immune response often observed in viral
infections. It is also intimately linked with the progression of COVID-19 disease as well as …

The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human …

A Amara, SD Penchala, L Else, C Hale… - … of pharmaceutical and …, 2021 - Elsevier
In light of the recent global pandemic, Molnupiravir (MPV) or EIDD-2801, developed for the
treatment of patients with uncomplicated influenza, is now being trialled for the treatment of …

Efficacy of repurposed antiviral drugs: Lessons from COVID-19

MA Martinez - Drug discovery today, 2022 - Elsevier
The clinical, social, and economic impacts of the coronavirus disease 2019 (COVID-19)
pandemic, originated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] 1, 4, 9, 9-tetramethyloctahydro-4, 7-(epoxymethano) azulen-5 (1H)-one, a natural product as a potential inhibitor of COVID-19: Extraction, crystal structure, and …

Y El Bakri, SK Mohamed, K Saravanan… - Journal of King Saud …, 2023 - Elsevier
In the present work, we describe the extraction of a natural product namely 1, 4, 9, 9-
tetramethyloctahydro-4, 7-(epoxymethano) azulen-5 (1H)-one, and its structure was …

[HTML][HTML] Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)

S Juul, EE Nielsen, J Feinberg, F Siddiqui… - PLoS …, 2020 - journals.plos.org
Background Coronavirus disease 2019 (COVID-19) is a rapidly spreading disease that has
caused extensive burden to individuals, families, countries, and the world. Effective …