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How COVID-19 has fundamentally changed clinical research in global health
JJH Park, R Mogg, GE Smith… - The Lancet Global …, 2021 - thelancet.com
COVID-19 has had negative repercussions on the entire global population. Despite there
being a common goal that should have unified resources and efforts, there have been an …
being a common goal that should have unified resources and efforts, there have been an …
COVID-19: characteristics and therapeutics
Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in
December 2019 is still haunting the entire human race and has affected not only the …
December 2019 is still haunting the entire human race and has affected not only the …
Multicenter interim guidance on use of antivirals for children with coronavirus disease 2019/severe acute respiratory syndrome coronavirus 2
K Chiotos, M Hayes, DW Kimberlin… - Journal of the …, 2021 - academic.oup.com
Background Although coronavirus disease 2019 (COVID-19) is a mild infection in most
children, a small proportion develop severe or critical illness. Data describing agents with …
children, a small proportion develop severe or critical illness. Data describing agents with …
Current strategies of antiviral drug discovery for COVID-19
M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …
BACPI: a bi-directional attention neural network for compound–protein interaction and binding affinity prediction
Motivation The identification of compound–protein interactions (CPIs) is an essential step in
the process of drug discovery. The experimental determination of CPIs is known for a large …
the process of drug discovery. The experimental determination of CPIs is known for a large …
COVID-19, cytokines, inflammation, and spices: How are they related?
Background Cytokine storm is the exaggerated immune response often observed in viral
infections. It is also intimately linked with the progression of COVID-19 disease as well as …
infections. It is also intimately linked with the progression of COVID-19 disease as well as …
The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human …
A Amara, SD Penchala, L Else, C Hale… - … of pharmaceutical and …, 2021 - Elsevier
In light of the recent global pandemic, Molnupiravir (MPV) or EIDD-2801, developed for the
treatment of patients with uncomplicated influenza, is now being trialled for the treatment of …
treatment of patients with uncomplicated influenza, is now being trialled for the treatment of …
Efficacy of repurposed antiviral drugs: Lessons from COVID-19
MA Martinez - Drug discovery today, 2022 - Elsevier
The clinical, social, and economic impacts of the coronavirus disease 2019 (COVID-19)
pandemic, originated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
pandemic, originated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
[HTML][HTML] 1, 4, 9, 9-tetramethyloctahydro-4, 7-(epoxymethano) azulen-5 (1H)-one, a natural product as a potential inhibitor of COVID-19: Extraction, crystal structure, and …
Y El Bakri, SK Mohamed, K Saravanan… - Journal of King Saud …, 2023 - Elsevier
In the present work, we describe the extraction of a natural product namely 1, 4, 9, 9-
tetramethyloctahydro-4, 7-(epoxymethano) azulen-5 (1H)-one, and its structure was …
tetramethyloctahydro-4, 7-(epoxymethano) azulen-5 (1H)-one, and its structure was …
[HTML][HTML] Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
S Juul, EE Nielsen, J Feinberg, F Siddiqui… - PLoS …, 2020 - journals.plos.org
Background Coronavirus disease 2019 (COVID-19) is a rapidly spreading disease that has
caused extensive burden to individuals, families, countries, and the world. Effective …
caused extensive burden to individuals, families, countries, and the world. Effective …