Background During neonatal and paediatric high-flow nasal cannula therapy, optimising the
flow setting is crucial for favourable physiological and clinical outcomes. However …

Introduction Transnasal aerosol drug delivery has become widely accepted for treating
acutely ill infants, children, and adults. More recently aerosol administration to wider …

The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …

Validation of a computational fluid dynamics (CFD) model used to simulate turbulent
exchange in an anatomically detailed human upper airway with realistic breathing states is …

Two working mechanisms of Nasal High-Flow Therapy (NHFT) are washout of anatomical
dead space and provision of positive end-expiratory pressure (PEEP). The extent of both …

BACKGROUND: The nasal cannula is widely regarded as a safe and effective means of
administering low-and high-flow oxygen to patients irrespective of their age. However …

Background The nasal cannula is considered a trusted and effective means of administering
low-flow oxygen and is widely used for neonates and infants requiring oxygen therapy …

Background. High‐flow nasal cannula (HFNC) oxygen therapy has been recommended for
use in coronavirus disease 2019 (COVID‐19) patients with acute respiratory failure and …

High flow nasal cannula (HFNC) therapy has been previously shown to produce positive
upper airway pressures in adult and child patients. This work aimed to evaluate and quantify …

Two types of high flow nasal cannula (HFNC) oxygen therapy were tested using
computational models of the human upper airway to investigate cannula geometry's effect …