Histology permits the observation of otherwise invisible structures of the internal topography
of a specimen. Although it enables the investigation of tissues at a cellular level, it is invasive …

Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …

MRI relaxometry is sensitive to a variety of tissue characteristics in a complex manner, which
makes it both attractive and challenging for characterizing tissue. This article reviews the …

Seminal human brain histology work has demonstrated developmental waves of
myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked …

The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …

Magnetization transfer (MT) imaging has been widely used for estimating myelin content in
the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R1 …

In an age‐heterogeneous sample of healthy adults, we examined test–retest reliability (with
and without participant repositioning) of two popular MRI methods of estimating myelin …

Over the last two decades, numerous human MRI studies of neuroplasticity have shown
compelling evidence for extensive and rapid experience-induced brain plasticity in vivo. To …

T1-weighted divided by T2-weighted (T1w/T2w) myelin maps were initially developed for
neuroanatomical analyses such as identifying cortical areas, but they are increasingly used …

Quantitative magnetic resonance imaging generates images of meaningful physical or
chemical variables measured in physical units that allow quantitative comparisons between …