Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
BO Roep, S Thomaidou, R van Tienhoven… - Nature Reviews …, 2021 - nature.com
Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …
100 years of insulin: celebrating the past, present and future of diabetes therapy
The year 2021 marks the centennial of Banting and Best's landmark description of the
discovery of insulin. This discovery and insulin's rapid clinical deployment effectively …
discovery of insulin. This discovery and insulin's rapid clinical deployment effectively …
Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial
Objective Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell
destruction. A gut microbiota–immunological interplay is involved in the pathophysiology of …
destruction. A gut microbiota–immunological interplay is involved in the pathophysiology of …
Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
The convergence of advances in medical science, human biology, data science, and
technology has enabled the generation of new insights into the phenotype known as …
technology has enabled the generation of new insights into the phenotype known as …
Management of latent autoimmune diabetes in adults: a consensus statement from an international expert panel
A substantial proportion of patients with adult-onset diabetes share features of both type 1
diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically …
diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically …
Adult-onset type 1 diabetes: current understanding and challenges
RD Leslie, C Evans-Molina, J Freund-Brown… - Diabetes …, 2021 - Am Diabetes Assoc
Recent epidemiological data have shown that more than half of all new cases of type 1
diabetes occur in adults. Key genetic, immune, and metabolic differences exist between …
diabetes occur in adults. Key genetic, immune, and metabolic differences exist between …
Type 1 diabetes
Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas
MA Atkinson, RG Mirmira - Cell Metabolism, 2023 - cell.com
Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …
A novel diabetes typology: towards precision diabetology from pathogenesis to treatment
C Herder, M Roden - Diabetologia, 2022 - Springer
The current classification of diabetes, based on hyperglycaemia, islet-directed antibodies
and some insufficiently defined clinical features, does not reflect differences in aetiological …
and some insufficiently defined clinical features, does not reflect differences in aetiological …
The clinical consequences of heterogeneity within and between different diabetes types
Advances in molecular methods and the ability to share large population-based datasets are
uncovering heterogeneity within diabetes types, and some commonalities between types …
uncovering heterogeneity within diabetes types, and some commonalities between types …