Meta‐analysis and Mendelian randomization: a review
Mendelian randomization (MR) uses genetic variants as instrumental variables to infer
whether a risk factor causally affects a health outcome. Meta‐analysis has been used …
whether a risk factor causally affects a health outcome. Meta‐analysis has been used …
BMP signalling in skeletal development, disease and repair
VS Salazar, LW Gamer, V Rosen - Nature Reviews Endocrinology, 2016 - nature.com
Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …
of bone and cartilage formation, BMP superfamily signalling has become one of the most …
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …
understood. To robustly characterize these effects, we performed a genome-wide …
A resource-efficient tool for mixed model association analysis of large-scale data
The genome-wide association study (GWAS) has been widely used as an experimental
design to detect associations between genetic variants and a phenotype. Two major …
design to detect associations between genetic variants and a phenotype. Two major …
New genetic loci link adipose and insulin biology to body fat distribution
D Shungin, TW Winkler, DC Croteau-Chonka… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
Largest GWAS of PTSD (N= 20 070) yields genetic overlap with schizophrenia and sex differences in heritability
Abstract The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-
PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic …
PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic …
Challenges and future directions for studying effects of host genetics on the gut microbiome
The human gut microbiome is a complex ecosystem that is involved in its host's metabolism,
immunity and health. Although interindividual variations in gut microbial composition are …
immunity and health. Although interindividual variations in gut microbial composition are …
Chapter 11: Genome-wide association studies
Genome-wide association studies (GWAS) have evolved over the last ten years into a
powerful tool for investigating the genetic architecture of human disease. In this work, we …
powerful tool for investigating the genetic architecture of human disease. In this work, we …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …
sequence variants at many genetic loci influence the phenotype. Genome-wide association …
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
Genome‐wide association studies (GWAS) can identify common alleles that contribute to
complex disease susceptibility. Despite the large number of SNPs assessed in each study …
complex disease susceptibility. Despite the large number of SNPs assessed in each study …