Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …

The molecular pathology of stress-related disorders remains elusive. Our brain multiregion,
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …

Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features,
including differential symptomatology, drug responsiveness, and male incidence rate. Prior …

Our earlier work has shown that genomic risk for schizophrenia converges with early life
complications in affecting risk for the disorder and sex-biased neurodevelopmental …

DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …

Objective: The authors sought to study the transcriptomic and genomic features of completed
suicide by parsing the method chosen, to capture molecular correlates of the distinctive …

Schizophrenia (SZ) and bipolar disorder (BP) are highly heritable major psychiatric
disorders that share a substantial portion of genetic risk as well as their clinical …

Antipsychotic drugs are the current first-line of treatment for schizophrenia and other
psychotic conditions. However, their molecular effects on the human brain are poorly …

Background: Cellular deconvolution of bulk RNA-sequencing (RNA-seq) data using single
cell or nuclei RNA-seq (sc/snRNA-seq) reference data is an important strategy for estimating …

Pathophysiology of many neuropsychiatric disorders, including schizophrenia (SCZD), is
linked to habenula (Hb) function. While pharmacotherapies and deep brain stimulation …