The expanding universe of p53 targets
D Menendez, A Inga, MA Resnick - Nature reviews Cancer, 2009 - nature.com
The p53 tumour suppressor is modified through mutation or changes in expression in most
cancers, leading to the altered regulation of hundreds of genes that are directly influenced …
cancers, leading to the altered regulation of hundreds of genes that are directly influenced …
Structure and stability of human telomeric sequence.
P Balagurumoorthy, SK Brahmachari - Journal of Biological Chemistry, 1994 - Elsevier
Telomeric DNA of a variety of vertebrates including humans contains the tandem repeat d
(TTAGGG) n. We have investigated the structural properties of the human telomeric repeat …
(TTAGGG) n. We have investigated the structural properties of the human telomeric repeat …
Comparative binding of p53 to its promoter and DNA recognition elements
RL Weinberg, DB Veprintsev, M Bycroft… - Journal of molecular …, 2005 - Elsevier
Tumor suppressor p53 is a transcription factor that transactivates a wide range of genes,
including those in DNA repair, cell cycle arrest, apoptosis and its own degradation. To …
including those in DNA repair, cell cycle arrest, apoptosis and its own degradation. To …
DNA structural forms
B Hartmann, R Lavery - Quarterly reviews of biophysics, 1996 - cambridge.org
In the years that have passed since the publication of Wolfram Saenger's classic book on
nucleic acid structure (Saenger, 1984), a considerable amount of new data has been …
nucleic acid structure (Saenger, 1984), a considerable amount of new data has been …
Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence
Little is known about the mechanisms that regulate differential transactivation by p53. We
developed a system in the yeast Saccharomyces cerevisiae that addresses p53 …
developed a system in the yeast Saccharomyces cerevisiae that addresses p53 …
NUPARM and NUCGEN: software for analysis and generation of sequence dependent nucleic acid structures
M Bansal, D Bhattacharyya, B Ravi - Bioinformatics, 1995 - academic.oup.com
Software packages NUFARM and NUCGEN, are described, which can be used to
understand sequence directed structural variations in nucleic acids, by analysis and …
understand sequence directed structural variations in nucleic acids, by analysis and …
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family
Q Ming, Y Roske, A Schuetz, K Walentin… - Nucleic acids …, 2018 - academic.oup.com
Abstract Grainyhead (Grh)/CP2 transcription factors are highly conserved in multicellular
organisms as key regulators of epithelial differentiation, organ development and skin barrier …
organisms as key regulators of epithelial differentiation, organ development and skin barrier …
p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting
DNA binding activity of p53 is crucial for its tumor suppressor function. Our recent studies
have shown that four molecules of the DNA binding domain of human p53 (p53DBD) bind …
have shown that four molecules of the DNA binding domain of human p53 (p53DBD) bind …
Crystal structure of a p53 core tetramer bound to DNA
KA Malecka, WC Ho, R Marmorstein - Oncogene, 2009 - nature.com
The tumor suppressor p53 regulates downstream genes in response to many cellular
stresses and is frequently mutated in human cancers. Here, we report the use of a …
stresses and is frequently mutated in human cancers. Here, we report the use of a …
Molecular strip** underpins derepression of a toxin–antitoxin system
Transcription factors control gene expression; among these, transcriptional repressors must
liberate the promoter for derepression to occur. Toxin–antitoxin (TA) modules are bacterial …
liberate the promoter for derepression to occur. Toxin–antitoxin (TA) modules are bacterial …