[HTML][HTML] Hallmarks of cancer: The CRISPR generation
The hallmarks of cancer were proposed as a logical framework to guide research efforts that
aim to understand the molecular mechanisms and derive treatments for this highly complex …
aim to understand the molecular mechanisms and derive treatments for this highly complex …
Epigenetic Editing : targeted rewriting of epigenetic marks to modulate expression of selected target genes
Despite significant advances made in epigenetic research in recent decades, many
questions remain unresolved, especially concerning cause and consequence of epigenetic …
questions remain unresolved, especially concerning cause and consequence of epigenetic …
Epigenetic reprogramming of cancer cells via targeted DNA methylation
An obstacle in the treatment of human diseases such as cancer is the inability to selectively
and effectively target historically undruggable targets such as transcription factors. Here, we …
and effectively target historically undruggable targets such as transcription factors. Here, we …
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic
protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are …
protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are …
Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter
H Chen, HG Kazemier, ML de Groote… - Nucleic acids …, 2014 - academic.oup.com
Increasing evidence indicates that active DNA demethylation is involved in several
processes in mammals, resulting in developmental stage-specificity and cell lineage …
processes in mammals, resulting in developmental stage-specificity and cell lineage …
Zinc fingers, TALEs, and CRISPR systems: a comparison of tools for epigenome editing
The completion of genome, epigenome, and transcriptome map** in multiple cell types
has created a demand for precision biomolecular tools that allow researchers to functionally …
has created a demand for precision biomolecular tools that allow researchers to functionally …
Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer
S Stolzenburg, MG Rots, AS Beltran, AG Rivenbark… - 2012 - academic.oup.com
The transcription factor (TF) SOX2 is essential for the maintenance of pluripotency and self-
renewal in embryonic stem cells. In addition to its normal stem cell function, SOX2 over …
renewal in embryonic stem cells. In addition to its normal stem cell function, SOX2 over …
Synthetically controlling dendrimer flexibility improves delivery of large plasmid DNA
Tools for editing the genome and epigenome have revolutionised the field of molecular
biology and represent a new frontier in targeted therapeutic intervention. Although …
biology and represent a new frontier in targeted therapeutic intervention. Although …
Activating PTEN tumor suppressor expression with the CRISPR/dCas9 system
PTEN expression is lost in many cancers, and even small changes in PTEN activity affect
susceptibility and prognosis in a range of highly aggressive malignancies, such as …
susceptibility and prognosis in a range of highly aggressive malignancies, such as …
Maspin: molecular mechanisms and therapeutic implications
TM Bodenstine, REB Seftor, Z Khalkhali-Ellis… - Cancer and Metastasis …, 2012 - Springer
Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been
characterized as a tumor suppressor gene in multiple cancer types. Among the established …
characterized as a tumor suppressor gene in multiple cancer types. Among the established …