Targeting CDK4 and CDK6 in cancer
Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …
transition into S phase and are important for the initiation, growth and survival of many …
Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
In silico protein interaction screening uncovers DONSON's role in replication initiation
CDC45-MCM2-7-GINS (CMG) helicase assembly is the central event in eukaryotic
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …
Treating cancer with selective CDK4/6 inhibitors
B O'leary, RS Finn, NC Turner - Nature reviews Clinical oncology, 2016 - nature.com
Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …
The CDK4/6 inhibitor revolution—A game-changing era for breast cancer treatment
Abstract Cyclin-dependent kinase (CDK) 4/6 inhibition in combination with endocrine
therapy is the standard-of-care treatment for patients with advanced-stage hormone receptor …
therapy is the standard-of-care treatment for patients with advanced-stage hormone receptor …
Stem cell quiescence: dynamism, restraint, and cellular idling
Stem cells can reside in a state of reversible growth arrest, or quiescence, for prolonged
periods of time. Although quiescence has long been viewed as a dormant, low-activity state …
periods of time. Although quiescence has long been viewed as a dormant, low-activity state …
Cyclin-dependent kinases (CDK) and their role in diseases development–review
P Łukasik, M Załuski, I Gutowska - International journal of molecular …, 2021 - mdpi.com
Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …
Identification of a cellularly active SIRT6 allosteric activator
SIRT6, a member of the SIRT deacetylase family, is responsible for deacetylation of histone
H3 N ε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor suppressor, SIRT6 has …
H3 N ε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor suppressor, SIRT6 has …
Cell cycle, CDKs and cancer: a changing paradigm
Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …
CDK inhibitors: positive and negative regulators of G1-phase progression
Mitogen-dependent progression through the first gap phase (G1) and initiation of DNA
synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by …
synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by …