Pharmacological targeting of IRE1 in cancer
DP Raymundo, D Doultsinos, X Guillory, A Carlesso… - Trends in cancer, 2020 - cell.com
IRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded
protein response (UPR). IRE1α plays instrumental protumoral roles in several cancers, and …
protein response (UPR). IRE1α plays instrumental protumoral roles in several cancers, and …
Dual RNase activity of IRE1 as a target for anticancer therapies
The unfolded protein response (UPR) is a cellular mechanism that protects cells during
stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic …
stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic …
Control of protein homeostasis in the early secretory pathway: current status and challenges
Discrimination between properly folded proteins and those that do not reach this state is
necessary for cells to achieve functionality. Eukaryotic cells have evolved several …
necessary for cells to achieve functionality. Eukaryotic cells have evolved several …
Capturing the antimicrobial profile of Paeonia officinalis, Jasminum officinale and Rosa damascene against methicillin resistant Staphylococcus aureus with …
In the current study, we evaluated the in vitro antibacterial efficacy of the roots' extracts of
Jasminum officinale, Rosa damascene and Paeonia officinalis against MRSA (methicillin …
Jasminum officinale, Rosa damascene and Paeonia officinalis against MRSA (methicillin …
Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition
RC Acúrcio, C Leonardo-Sousa, AT García-Sosa… - …, 2019 - pubs.rsc.org
Programmed cell death protein 1 (PD-1) and PD-ligand 1 (PD-L1) interaction plays an
important role in cancer immunotherapy. Several PD-1/PD-L1 inhibitors have been …
important role in cancer immunotherapy. Several PD-1/PD-L1 inhibitors have been …
Effect of kinase inhibiting rnase attenuator (Kira) compounds on the formation of face-to-face dimers of inositol-requiring enzyme 1: Insights from computational …
Inositol-requiring enzyme 1α (IRE1α) is a transmembrane dual kinase/ribonuclease protein
involved in propagation of the unfolded protein response (UPR). Inositol-requiring enzyme …
involved in propagation of the unfolded protein response (UPR). Inositol-requiring enzyme …
Structure-Based Drug Design for Targeting IRE1: An in Silico Approach for Treatment of Cancer
Background Endoplasmic Reticulum (ER) stress and Unfolded Protein Response (UPR)
play a key role in cancer progression. The aggregation of incorrectly folded proteins in the …
play a key role in cancer progression. The aggregation of incorrectly folded proteins in the …
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
A Carlesso - 2019 - gupea.ub.gu.se
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and
endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) …
endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) …
Structural distortions induced by Kinase Inhibiting RNase Attenuator (KIRA) compounds prevent the formation of face-to-face dimers of Inositol Requiring Enzyme 1α
Abstract Inositol-Requiring Enzyme 1α (IRE1α) is a transmembrane dual
kinase/ribonuclease protein involved in propagation of the unfolded protein response …
kinase/ribonuclease protein involved in propagation of the unfolded protein response …
[HTML][HTML] Inositolo: Perché il tuo organismo ha bisogno della Vitamina B8?
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▷ Inositolo: Proprietà, Funzioni ed Effetti [Blog HSN] Autori Visita il nostro negozio IT es pt fr
en de IT es pt fr en de Visita il nostro negozio Autori Blog di Fitness, Nutrizione, Salute e Sport …
en de IT es pt fr en de Visita il nostro negozio Autori Blog di Fitness, Nutrizione, Salute e Sport …