Mining of integrated public transcriptomic and ChIP-Seq (cistromic) datasets can illuminate
functions of mammalian cellular signaling pathways not yet explored in the research …

Summary The Gene Expression Omnibus (GEO) has millions of samples from thousands of
studies. While users of GEO can search the metadata describing studies, there is a need for …

Chemical pollutant exposure is a risk factor contributing to the growing epidemic of non-
alcoholic fatty liver disease (NAFLD) affecting human populations that consume a western …

Transcriptional perturbation signatures are valuable data sources for functional genomics.
Linking perturbation signatures to screenings opens the possibility to model cellular …

Conventional drug discovery in general is costly and time-consuming with extremely low
success and relatively high attrition rates. The disparity between high cost of drug discovery …

Non-alcoholic steatohepatitis (NASH) is a rising health challenge, with no approved drugs.
We used a computational drug repositioning strategy to uncover a novel therapy for NASH …

The omics area that, was developed the past decades, has offered a basis for the
development of systems biology technologies that include the integration of several omics …