Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

The use of animals as models of human physiology is, and has been for many years, an
indispensable tool for understanding the mechanisms of human disease. In Parkinson's …

Background Circadian disturbance is a common nonmotor complaint in Parkinson's disease
(PD). The molecular basis underlying circadian rhythm in PD is poorly understood …

Aims Adverse cardiovascular events have day/night patterns with peaks in the morning,
potentially related to endogenous circadian clock control of platelet activation. Circadian …

Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …

All organisms have various circadian, behavioral, and physiological 24-h periodic rhythms,
which are controlled by the circadian clock. The circadian clock controls various behavioral …

Parkinson's disease (PD) is the second most common neurodegenerative disease, which
manifests with both motor and non-motor symptoms. Circadian rhythm dysregulation, as one …

Cortical microglia exhibit a ramified shape during sleep, while they have a hyper-ramified
shape during wakefulness, which is characterized by their longer processes with increased …

Circadian rhythms are involved in the regulation of many aspects of the body, including cell
function, physical activity and disease. Circadian disturbance often predates the typical …

The circadian clock regulates various physiological processes, including bone metabolism.
The nuclear receptors Rev-erbs, comprising Rev-erbα and Rev-erbβ, play a key role as …