FTO–a common genetic basis for obesity and cancer

N Lan, Y Lu, Y Zhang, S Pu, H **, X Nie, J Liu… - Frontiers in …, 2020 - frontiersin.org
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a
serious threat to human health, the relationship between the two has attracted much …

Obesity and Inflammation Lead to Insulin Resistance and Cancer—A Systematic Review

M Shafiul Hossen, M Abdul Barek… - Obesity: Clinical, Surgical …, 2024 - Springer
Adipose tissue mass is increased in obese people due to the increasing size and number of
adipocytes. It significantly changes the adipocytokines and inflammatory mediators secretion …

Obesity and breast cancer: molecular interconnections and potential clinical applications

V Simone, M D'avenia, A Argentiero, C Felici… - The …, 2016 - academic.oup.com
Obesity is an important risk factor for breast cancer (BC) in postmenopausal women;
interlinked molecular mechanisms might be involved in the pathogenesis. Increased levels …

The potential role of N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene (FTO) in human cancers

J Wang, L Chen, P Qiang - OncoTargets and therapy, 2020 - Taylor & Francis
Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene
(FTO), previously recognized to be related with obesity and diabetes, was gradually …

Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases

BC Melnik - Journal of translational medicine, 2015 - Springer
Single-nucleotide polymorphisms within intron 1 of the FTO (fat mass and obesity-
associated) gene are associated with enhanced FTO expression, increased body weight …

Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview

ME Hernández-Caballero, JA Sierra-Ramírez - Molecular biology reports, 2015 - Springer
The FTO (fat mass and obesity-associated) gene has a strong linkage disequilibrium block,
within which SNPs have been identified that are involved in the development of obesity …

ADAR1-mediated RNA editing promotes B cell lymphomagenesis

R Pecori, W Ren, M Pirmoradian, X Wang, D Liu… - Iscience, 2023 - cell.com
Diffuse large B cell lymphoma (DLBCL) is one of the most common types of aggressive
lymphoid malignancies. Here, we explore the contribution of RNA editing to DLBCL …

Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by …

S Li, L Cao - Bioengineered, 2022 - Taylor & Francis
ABSTRACT N6-Methyladenosine (m6A) is the most abundant modifications in human
messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism …

Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta‐analysis

X Huang, J Zhao, M Yang, M Li… - European journal of …, 2017 - Wiley Online Library
Obesity is a risk factor of cancer. Several genes have been found to play an important role in
aetiology of obesity and tumourigenesis. Recently, some studies suggested that rs9939609 …

Estrogen promotes fat mass and obesity-associated protein nuclear localization and enhances endometrial cancer cell proliferation via the mTOR signaling pathway

Y Zhu, J Shen, L Gao, Y Feng - Oncology reports, 2016 - spandidos-publications.com
Extensive exposure to estrogen is generally acknowledged as a risk factor for endometrial
cancer. Given that the accumulation of adipocytes also contributes to the increased …