A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

In the central nervous system, NG2‐glia represent a neural cell population that is distinct
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …

Following CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …

The adult brain parenchyma contains a widespread population of progenitors generating
different cells of the oligodendrocyte lineage such as NG2+ cells and some mature …

Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous
system, facilitates water movement into and out of the brain. Here, we identify a novel role for …

Aquaporin-4 (AQP4) is expressed in astrocytes throughout the central nervous system,
particularly at the blood–brain and brain–cerebrospinal fluid barriers. Phenotype analysis of …

A major hurdle for regeneration after spinal cord injury (SCI) is the ability of axons to
penetrate and grow through the scar tissue. After SCI, inflammatory cells, astrocytes and …

It is well established that axonal regeneration in the adult CNS is largely unsuccessful.
Numerous axon‐inhibitory molecules are now known to be present in the injured CNS, and …

Chondroitin sulfate proteoglycan (CS-PG) expression is increased in response to CNS injury
and limits the capacity for axonal regeneration. Previously we have shown that neurocan is …

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in both injury
and repair mechanisms in the CNS. Pharmacological blockade of MMPs, limited to the first …