Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
Consciousness among delta waves: a paradox?
A common observation in EEG research is that consciousness vanishes with the
appearance of delta (1–4 Hz) waves, particularly when those waves are high amplitude …
appearance of delta (1–4 Hz) waves, particularly when those waves are high amplitude …
NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex
Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the
absence of sensory stimulation, the foundation of mental representation. Persistent firing …
absence of sensory stimulation, the foundation of mental representation. Persistent firing …
Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice
Ketamine treatment decreases depressive symptoms within hours, but the mechanisms
mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity …
mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity …
Reviewing the ketamine model for schizophrenia
The observation that antagonists of the N-methyl-D-aspartate receptor (NMDAR), such as
phencyclidine (PCP) and ketamine, transiently induce symptoms of acute schizophrenia had …
phencyclidine (PCP) and ketamine, transiently induce symptoms of acute schizophrenia had …
NMDAR hypofunction animal models of schizophrenia
The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …
Ketamine and phencyclidine: the good, the bad and the unexpected
D Lodge, MS Mercier - British journal of pharmacology, 2015 - Wiley Online Library
The history of ketamine and phencyclidine from their development as potential clinical
anaesthetics through drugs of abuse and animal models of schizophrenia to potential …
anaesthetics through drugs of abuse and animal models of schizophrenia to potential …
Reduced sleep spindle activity point to a TRN-MD thalamus-PFC circuit dysfunction in schizophrenia
Sleep disturbances have been reliably reported in patients with schizophrenia, thus
suggesting that abnormal sleep may represent a core feature of this disorder. Traditional …
suggesting that abnormal sleep may represent a core feature of this disorder. Traditional …
[PDF][PDF] Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male …
M Niesters, N Khalili-Mahani, C Martini, L Aarts… - …, 2012 - academia.edu
Background: The influence of psychoactive drugs on the central nervous system has been
investigated with positron emission tomography and task-related functional magnetic …
investigated with positron emission tomography and task-related functional magnetic …
Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research
The pharmacological modulation of glutamatergic neurotransmission to improve cognitive
function has been a focus of intensive research, particularly in relation to the cognitive …
function has been a focus of intensive research, particularly in relation to the cognitive …