Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …

Crohn's disease (CD) is a complex chronic inflammatory disorder with both gastrointestinal
and extra-intestinal manifestations associated immune dysregulation. Analyzing 202,359 …

Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity,
but how human-associated bacteria impact Th17-driven disease remains elusive. We show …

The interaction between host and external environment mainly occurs in the gastrointestinal
tract, where the mucosal barrier has a critical role in many physiologic functions ranging …

The gut microbiome plays a central role in inflammatory bowel diseases (IBDs)
pathogenesis and propagation. To determine whether the gut microbiome may predict …

Altered intestinal permeability plays a role in many pathological conditions. Intestinal
permeability is a component of the intestinal barrier. This barrier is a dynamic interface …

Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and
relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory …

Some of the most common symptoms of the inflammatory bowel diseases (IBD, which
include ulcerative colitis and Crohn's disease) are abdominal pain, diarrhea, and weight …

Intestinal epithelial cells (IECs) line the surface of intestinal epithelium, where they play
important roles in the digestion of food, absorption of nutrients, and protection of the human …