Calibrated prediction intervals for polygenic scores across diverse contexts
Polygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide
range of fields. We show that PGS performance varies broadly across contexts and …
range of fields. We show that PGS performance varies broadly across contexts and …
Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
Genome-wide discovery for biomarkers using quantile regression at biobank scale
Genome-wide association studies (GWAS) for biomarkers important for clinical phenotypes
can lead to clinically relevant discoveries. Conventional GWAS for quantitative traits are …
can lead to clinically relevant discoveries. Conventional GWAS for quantitative traits are …
Statistical methods for gene–environment interaction analysis
Most human complex phenotypes result from multiple genetic and environmental factors and
their interactions. Understanding the mechanisms by which genetic and environmental …
their interactions. Understanding the mechanisms by which genetic and environmental …
Evaluating the continued integration of genetics into medical sociology
The 2010 special issue of Journal of Health and Social Behavior, titled “Fifty Years of
Medical Sociology,” defined the contours of the medical sociological perspective. We use …
Medical Sociology,” defined the contours of the medical sociological perspective. We use …
Gene-by-peer-environment interaction effects on cigarette, alcohol, and marijuana use among US high school students of European Ancestry
Research has shown that adolescents' substance use behavior is determined not only by
individual characteristics but also by peer environments, and an emerging literature in social …
individual characteristics but also by peer environments, and an emerging literature in social …
Reimagining gene-environment interaction analysis for human complex traits
In this study, we introduce PIGEON—a novel statistical framework for quantifying and
estimating polygenic gene-environment interaction (GxE) using a variance component …
estimating polygenic gene-environment interaction (GxE) using a variance component …
[HTML][HTML] Interaction of family SES with children's genetic propensity for cognitive and noncognitive skills: No evidence of the Scarr-Rowe hypothesis for educational …
This study examines the role of genes and environments in predicting educational
outcomes. We test the Scarr-Rowe hypothesis, suggesting that enriched environments …
outcomes. We test the Scarr-Rowe hypothesis, suggesting that enriched environments …
Characterization of gene-environment interactions for vitamin D through variance quantitative trait loci: a UK Biobank-based genetic epidemiology study
Background Understanding gene-environment interactions associated with vitamin D status
may refine nutrition and public health strategies for vitamin D deficiency. Recent …
may refine nutrition and public health strategies for vitamin D deficiency. Recent …
Detecting gene–environment interactions from multiple continuous traits
WY Lin - Bioinformatics, 2024 - academic.oup.com
Motivation Genetic variants present differential effects on humans according to various
environmental exposures, the so-called “gene–environment interactions”(GxE). Many …
environmental exposures, the so-called “gene–environment interactions”(GxE). Many …