Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

Kidneys are central in the regulation of multiple physiological functions, such as removal of
metabolic wastes and toxins, maintenance of electrolyte and fluid balance, and control of pH …

The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …

Background The calcium-sensing receptor (CaSR) in the distal convoluted tubule (DCT)
activates the NaCl cotransporter (NCC). Glucose acts as a positive allosteric modulator of …

Extracellular fluid calcium concentration must be maintained within a narrow range in order
to sustain many biological functions, encompassing muscle contraction, blood coagulation …

Background Treatment with alkali has been hypothesized to improve bone health in CKD by
mitigating adverse effects of acid on bone mineral. We investigated the effect of treatment …

Regulation of the WNK4-SPAK-NCC pathway by the calcium-sensi... : Current Opinion in
Nephrology and Hypertension Regulation of the WNK4-SPAK-NCC pathway by the calcium-sensing …

New discoveries relating to phosphorus homeostasis include the hormones fibroblast
growth factor-23 and klotho produced by bone and kidney. These hormones, together with …

Chronic kidney disease (CKD) is characterized by progressive reduction in kidney function
and treatments aiming at stabilizing or slowing its progression may avoid or delay the …