N-Heterocyclic carbenes, despite being isolated and characterized three decades ago, still
capture scientists' interest as versatile, modular and strongly coordinating moieties. In the …

Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Cancer metastasis accounts for the major cause of cancer-related deaths. How
disseminated cancer cells cope with hostile microenvironments in secondary site for full …

Millions of years of evolution have produced biological systems capable of efficient one-pot
multi-step catalysis. The underlying mechanisms that facilitate these reaction processes are …

The mitochondrial pyruvate dehydrogenase complex (PDC) irreversibly decarboxylates
pyruvate to acetyl coenzyme A, thereby linking glycolysis to the tricarboxylic acid cycle and …

DNA transcription, replication, and repair are regulated by histone acetylation, a process that
requires the generation of acetyl-coenzyme A (CoA). Here, we show that all the subunits of …

Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the
treatment of obesity. However, pharmacologic engagement of this process has proven …

Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging.
Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no …

Recently, cuproptosis has been demonstrated to be a new non-apototic cell death mode that
is characterized by copper dependence and the regulation of mitochondrial respiration …