Blood platelets have long been recognised to bring about primary haemostasis with
deficiencies in platelet production and function manifesting in bleeding while upregulated …

The population suffering from coronary heart disease (CHD) complicated by atrial fibrillation
(AF) is rising rapidly. A strong correlation between the two diseases has been reported, and …

Atrial fibrillation (AF) is associated with an increased risk of myocardial infarction (MI) and
vice versa. This bidirectional association relies on shared risk factors as well as on several …

Background A growing body of evidence suggests that atrial fibrillation (AF) is associated
with myocardial infarction (MI). However, incidence and management of MI in AF is still …

The role of CD40/CD40 ligand (CD40L) in atherothrombosis is now widely accepted.
However, the exact mechanisms linking the CD40/CD40L system and the soluble form of …

Extensive evidence implicates inflammation in multiple phases of stroke etiology and
pathology. In particular, there is growing awareness that inflammatory events outside the …

Objective: To investigate the influence of common and low-frequency genetic variants on the
risk of ischemic stroke (all IS) and etiologic stroke subtypes. Methods: We meta-analyzed 12 …

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Platelets are the main players in thrombotic diseases, where activated platelets not only
mediate thrombus formation but also are involved in multiple interactions with vascular cells …

Abstract The CD40-CD40L system is a pathway which is associated with both prothrombotic
and proinflammatory effects. CD40 and its ligand were first discovered on the surface of …