COVID-19: Immunology and treatment options

S Felsenstein, JA Herbert, PS McNamara… - Clinical …, 2020 - Elsevier
The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. As
protective immunity does not exist in humans and the virus is capable of esca** innate …

Convalescent plasma or hyperimmune immunoglobulin for people with COVID‐19: a living systematic review

I Monsef, C Doree, EM Wood… - Cochrane Database …, 2020 - cochranelibrary.com
Background Convalescent plasma and hyperimmune immunoglobulin may reduce mortality
in patients with viral respiratory diseases, and are currently being investigated in trials as …

Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)

W Alhazzani, MH Møller, YM Arabi, M Loeb… - Intensive care …, 2020 - Springer
Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting …

Antiviral approaches against influenza virus

R Kumari, SD Sharma, A Kumar, Z Ende… - Clinical microbiology …, 2023 - Am Soc Microbiol
Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …

Critical care management of adults with community-acquired severe respiratory viral infection

YM Arabi, R Fowler, FG Hayden - Intensive care medicine, 2020 - Springer
With the expanding use of molecular assays, viral pathogens are increasingly recognized
among critically ill adult patients with community-acquired severe respiratory illness; studies …

Convalescent plasma or hyperimmune immunoglobulin for people with COVID‐19: a living systematic review

SJ Valk, C Kimber, E Dorando, I Monsef… - Cochrane Database …, 2021 - cochranelibrary.com
Background Convalescent plasma and hyperimmune immunoglobulin may reduce mortality
in patients with viral respiratory diseases, and are being investigated as potential therapies …

Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits

S Ravichandran, EM Coyle, L Klenow, J Tang… - Science translational …, 2020 - science.org
Multiple vaccine candidates against SARS-CoV-2 based on viral spike protein are under
development. However, there is limited information on the quality of antibody responses …

The use of intravenous immunoglobulin gamma for the treatment of severe coronavirus disease 2019: a randomized placebo-controlled double-blind clinical trial

N Gharebaghi, R Nejadrahim, SJ Mousavi… - BMC infectious …, 2020 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) has infected people in many
countries worldwide. Discovering an effective treatment for this disease, particularly in …

Serodiagnostics for Severe Acute Respiratory Syndrome–Related Coronavirus 2: A Narrative Review

MP Cheng, CP Yansouni, NE Basta… - Annals of internal …, 2020 - acpjournals.org
Accurate serologic tests to detect host antibodies to severe acute respiratory syndrome–
related coronavirus 2 (SARS-CoV-2) will be critical for the public health response to the …

Comparative effectiveness of combined favipiravir and oseltamivir therapy versus oseltamivir monotherapy in critically ill patients with influenza virus infection

Y Wang, G Fan, A Salam, P Horby… - The Journal of …, 2020 - academic.oup.com
Background A synergistic effect of combination therapy with favipiravir and oseltamivir has
been reported in preclinical models of influenza. However, no data are available on the …