Technological advances have dramatically expanded our ability to probe multi-neuronal
dynamics and connectivity in the brain. However, our ability to extract a simple conceptual …

The loss of a limb or paralysis resulting from spinal cord injury has devastating
consequences on quality of life. One approach to restoring lost sensory and motor abilities in …

Despite the rapid progress and interest in brain-machine interfaces that restore motor
function, the performance of prosthetic fingers and limbs has yet to mimic native function …

In many experiments, neuroscientists tightly control behavior, record many trials, and obtain
trial-averaged firing rates from hundreds of neurons in circuits containing billions of …

Neural prostheses translate neural activity from the brain into control signals for guiding
prosthetic devices, such as computer cursors and robotic limbs, and thus offer individuals …

Arm movement is well represented in populations of neurons recorded from the motor
cortex,,,,,,. Cortical activity patterns have been used in the new field of brain–machine …

Brain-computer interface (BCI) can be used as a real-time bidirectional information gateway
between the brain and machines. In particular, rapid progress in invasive BCI, propelled by …

The nature of nervous system function and development is inherently global, since all
components eventually influence one another. Networks communicate through dense …

Computer-mediated connections between human motor cortical neurons and assistive
devices promise to improve or restore lost function in people with paralysis. Recently, a pilot …

Experiments on humans and other animals have shown that uncertainty due to unreliable or
incomplete information affects behavior. Recent studies have formalized uncertainty and …