The major arteries and veins of the vertebrate circulatory system are formed early in
embryonic development, before the onset of circulation, following de novo aggregation of …

The zebrafish has emerged as an excellent vertebrate model system for studying blood and
lymphatic vascular development. The small size, external and rapid development, and …

Summary Norrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control
retinal vascular development. Using genetically engineered mice, we show that precocious …

The functional diversity of the arterial and venous endothelia is regulated through a complex
system of signalling pathways and downstream transcription factors. Here we report that the …

Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …

Disorders of vascular structure and function play a central role in a wide variety of CNS
diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 coreceptor, or Norrin ligand cause …

The transcription factors that regulate endothelial cell development have been a focus of
active research for several years, and many players in the endothelial transcriptional …

Blood vessels form de novo (vasculogenesis) or upon sprouting of capillaries from
preexisting vessels (angiogenesis). With high-resolution imaging of zebrafish vascular …

In metazoa, SOX family transcription factors play many diverse roles. In vertebrate, they are
well-known regulators of numerous developmental processes. Wide-ranging studies have …

The formation of a hierarchical vascular network, composed of arteries, veins, and
capillaries, is essential for embryogenesis and is required for the production of new …