Importance Epilepsy surgery is indicated for patients with focal seizures who do not respond
to appropriate antiepileptic drug therapy consisting of 2 or more medications. Objectives To …

Abstract Seizures in some 30% to 40% of patients with epilepsy fail to respond to
antiepileptic drugs or other treatments. While much has been made of the risks of new drug …

Objective To prospectively evaluate safety and efficacy of brain-responsive neurostimulation
in adults with medically intractable focal onset seizures (FOS) over 9 years. Methods Adults …

Epilepsy surgery is the most effective way to control seizures in patients with drug-resistant
focal epilepsy, often leading to improvements in cognition, behaviour, and quality of life …

Cognitive comorbidities are very common in epilepsy and often seen as secondary to
epilepsy or caused by epilepsy. The implicit and sometimes explicit assumption is that …

The epilepsies are a heterogeneous group of disorders characterized by the propensity to
experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the …

Assessment of long-term outcomes is essential in brain surgery for epilepsy, which is an
irreversible intervention for a chronic condition. Excellent short-term results of resective …

Purpose: Epilepsy surgery is a safe surgical procedure, but it may be associated with
cognitive changes. Estimates of the risk of decline in specific neuropsychological domains …

Understanding the long association pathways that convey cortical connections is a critical
step in exploring the anatomic substrates of cognition in health and disease. Diffusion tensor …

Surgery is widely accepted as an effective therapy for selected individuals with medically
refractory epilepsy. Numerous studies in the past 20 years have reported seizure freedom …