Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS)
Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …
examination and characterization of lipids directly from biological materials. The successful …
Mass spectrometry imaging in drug development
Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
Categorizing cells on the basis of their chemical profiles: progress in single-cell mass spectrometry
The chemical differences between individual cells within large cellular populations provide
unique information on organisms' homeostasis and the development of diseased states …
unique information on organisms' homeostasis and the development of diseased states …
Lipid imaging by mass spectrometry–a review
D Gode, DA Volmer - Analyst, 2013 - pubs.rsc.org
Mass spectrometry imaging (MSI) has proven to be extremely useful for applications such as
the spatial analysis of peptides and proteins in biological tissue, the performance …
the spatial analysis of peptides and proteins in biological tissue, the performance …
Secondary ion mass spectrometry: characterizing complex samples in two and three dimensions
Over the last 10 or so years, developments in molecular se-condary ion mass spectrometry
(SIMS) have taken its capability into areas previously only demonstrated in dynamic SIMS …
(SIMS) have taken its capability into areas previously only demonstrated in dynamic SIMS …
Single-cell lipidomics: characterizing and imaging lipids on the surface of individual Aplysia californica neurons with cluster secondary ion mass spectrometry
Neurons isolated from Aplysia californica, an organism with a well-defined neural network,
were imaged with secondary ion mass spectrometry, C60-SIMS. A major lipid component of …
were imaged with secondary ion mass spectrometry, C60-SIMS. A major lipid component of …
Imaging mass spectrometry of thin tissue sections: a decade of collective efforts
P Chaurand - Journal of proteomics, 2012 - Elsevier
Imaging mass spectrometry (MS) allows to monitor the spatial distribution and abundance of
endogenous and administered compounds present within tissue specimens. Several …
endogenous and administered compounds present within tissue specimens. Several …
Mass spectrometry imaging, an emerging technology in neuropsychopharmacology
M Shariatgorji, P Svenningsson… - …, 2014 - nature.com
Mass spectrometry imaging is a powerful tool for directly determining the distribution of
proteins, peptides, lipids, neurotransmitters, metabolites and drugs in neural tissue sections …
proteins, peptides, lipids, neurotransmitters, metabolites and drugs in neural tissue sections …
Recent advances in the development of single cell analysis—A review
K Klepárník, F Foret - Analytica chimica acta, 2013 - Elsevier
Abstract Development of techniques for the analysis of the content of individual cells
represents an important direction in modern bioanalytical chemistry. While the analysis of …
represents an important direction in modern bioanalytical chemistry. While the analysis of …
Imaging of lipids in native human bone sections using TOF–secondary ion mass spectrometry, atmospheric pressure scanning microprobe matrix-assisted laser …
K Schaepe, DR Bhandari, J Werner, A Henss… - Analytical …, 2018 - ACS Publications
A method is described for high-resolution label-free molecular imaging of human bone
tissue. To preserve the lipid content and the heterogeneous structure of osseous tissue, 4 …
tissue. To preserve the lipid content and the heterogeneous structure of osseous tissue, 4 …