Actin dynamics, architecture, and mechanics in cell motility

L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Force feedback controls motor activity and mechanical properties of self-assembling branched actin networks

P Bieling, J Weichsel, R McGorty, P Jreij, B Huang… - Cell, 2016 - cell.com
Branched actin networks—created by the Arp2/3 complex, cap** protein, and a nucleation
promoting factor—generate and transmit forces required for many cellular processes, but …

EasyFRAP-web: a web-based tool for the analysis of fluorescence recovery after photobleaching data

G Koulouras, A Panagopoulos… - Nucleic acids …, 2018 - academic.oup.com
Understanding protein dynamics is crucial in order to elucidate protein function and
interactions. Advances in modern microscopy facilitate the exploration of the mobility of …

Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism

JD Winkelman, CA Anderson… - Proceedings of the …, 2020 - National Acad Sciences
The actin cytoskeleton assembles into diverse load-bearing networks, including stress fibers
(SFs), muscle sarcomeres, and the cytokinetic ring to both generate and sense mechanical …

Tau co-organizes dynamic microtubule and actin networks

A Elie, E Prezel, C Guérin, E Denarier… - Scientific reports, 2015 - nature.com
The crosstalk between microtubules and actin is essential for cellular functions. However,
mechanisms underlying the microtubule-actin organization by cross-linkers remain largely …

Analysis of turnover dynamics of the submembranous actin cortex

M Fritzsche, A Lewalle, T Duke, K Kruse… - Molecular biology of …, 2013 - Am Soc Cell Biol
The cell cortex is a thin network of actin, myosin motors, and associated proteins that
underlies the plasma membrane in most eukaryotic cells. It enables cells to resist …

Mathematical modeling of eukaryotic cell migration: insights beyond experiments

G Danuser, J Allard, A Mogilner - Annual review of cell and …, 2013 - annualreviews.org
A migrating cell is a molecular machine made of tens of thousands of short-lived and
interacting parts. Understanding migration means understanding the self-organization of …

Fascin-and α-actinin-bundled networks contain intrinsic structural features that drive protein sorting

JD Winkelman, C Suarez, GM Hocky, AJ Harker… - Current Biology, 2016 - cell.com
Cells assemble and maintain functionally distinct actin cytoskeleton networks with various
actin filament organizations and dynamics through the coordinated action of different sets of …

The cytoskeleton of the retinal pigment epithelium: from normal aging to age-related macular degeneration

IS Tarau, A Berlin, CA Curcio, T Ach - International journal of molecular …, 2019 - mdpi.com
The retinal pigment epithelium (RPE) is a unique epithelium, with major roles which are
essential in the visual cycle and homeostasis of the outer retina. The RPE is a monolayer of …