Genetics and biology of prostate cancer
Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
Molecular genetics of prostate cancer: new prospects for old challenges
Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …
cancer-related mortality and morbidity in men. Since early studies on the role of the …
[HTML][HTML] AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox …
TC Chen, JY Chuang, CY Ko, TJ Kao, PY Yang, CH Yu… - Redox biology, 2020 - Elsevier
Drug resistance is the main obstacle in the improvement of chemotherapeutic efficacy in
glioblastoma. Previously, we showed that dehydroepiandrosterone (DHEA), one kind of …
glioblastoma. Previously, we showed that dehydroepiandrosterone (DHEA), one kind of …
Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis
The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …
[HTML][HTML] The molecular and cellular origin of human prostate cancer
JR Packer, NJ Maitland - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …
epidemiology, there are no definitive aetiological clues linking development to frequency …
Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants
The SPOP E3 ubiquitin ligase gene is frequently mutated in human prostate cancers. Here,
we demonstrate that SPOP recognizes a Ser/Thr-rich degron in the hinge domain of …
we demonstrate that SPOP recognizes a Ser/Thr-rich degron in the hinge domain of …
Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence
The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the
lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …
lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …
Effects of MTX-23, a novel PROTAC of androgen receptor splice variant-7 and androgen receptor, on CRPC resistant to second-line antiandrogen therapy
GT Lee, N Nagaya, J Desantis, K Madura… - Molecular cancer …, 2021 - AACR
Although second-line antiandrogen therapy (SAT) is the standard of care in men with
castration-resistant prostate cancer (CRPC), resistance inevitably occurs. One major …
castration-resistant prostate cancer (CRPC), resistance inevitably occurs. One major …
The androgen receptor in health and disease
T Matsumoto, M Sakari, M Okada… - Annual review of …, 2013 - annualreviews.org
Androgens play pivotal roles in the regulation of male development and physiological
processes, particularly in the male reproductive system. Most biological effects of androgens …
processes, particularly in the male reproductive system. Most biological effects of androgens …