In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …

The significance of 3D cell culture—ie, the maintenance of cell characteristics by mimicking
the natural environment—has been increasing, and various 3D cell culture methods have …

To date, anticancer therapies with evidenced efficacy in preclinical models fail during clinical
trials. The shortage of robust drug screening platforms that accurately predict patient's …

Background We propose a new approach for designing personalized treatment for
colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with …

Background Preclinical cell-based assays that recapitulate human disease play an
important role in drug repurposing. We previously developed a functional forskolin induced …

A series of novel mono and bishydrazones each bearing a 2-oxindole moiety along with
substituted phenylaminopropanamide, pyrrolidin-2-one, benzimidazole, diphenylmethane …

Pectins are a class of soluble polysaccharides that can have anticancer properties through
several mechanisms. This study aimed to characterize the molecular structure of water …

Although Raman spectroscopy has been used for the quantitative analysis of samples in
many fields, including material science, biomedical, and pharmaceutical research, its low …

Colorectal cancer is one of the most important malignancies worldwide, with high incidence
and mortality rates. Several studies have been conducted using two-dimensional cultured …

Some insects form symbioses in which actinomycetes provide defense against pathogens
by making antimicrobials. The range of chemical strategies employed across these …