In the past decade, hyperpolarized (HP) contrast agents have been under active
development for MRI applications to address the twin challenges of functional and …

MRI with hyperpolarized carbon‐13 agents has created a new type of noninvasive, in vivo
metabolic imaging that can be applied in cell, animal, and human studies. The use of 13C …

MRI using hyperpolarized (HP) carbon‐13 pyruvate is being investigated in clinical trials to
provide non‐invasive measurements of metabolism for cancer and cardiac imaging. In this …

Purpose To develop and translate a metabolite‐specific imaging sequence using a
symmetric echo planar readout for clinical hyperpolarized (HP) Carbon‐13 (13C) …

Purpose To ameliorate tradeoffs between a fixed spatial resolution and signal‐to‐noise ratio
(SNR) for hyperpolarized 13C MRI. Methods In MRI, SNR is proportional to voxel volume but …

Based on the expanding set of applications for hyperpolarized carbon‐13 (HP‐13C) MRI,
this work aims to communicate standardized methodology implemented at the University of …

Kinetic modeling of the in vivo pyruvate-to-lactate conversion is crucial to investigating
aberrant cancer metabolism that demonstrates Warburg effect modifications. Non-invasive …

Purpose Acquisition timing and B1 calibration are two key factors that affect the quality and
accuracy of hyperpolarized 13C MRI. The goal of this project was to develop a new …

Hyperpolarized metabolic MRI with 13 C-labeled agents has emerged as a powerful
technique for in vivo assessments of real-time metabolism that can be used across scales of …

Hyperpolarization is an emerging method in magnetic resonance imaging that allows
nuclear spin polarization of gases or liquids to be temporarily enhanced by up to five or six …