Therapeutic potential of endothelial colony-forming cells in ischemic disease: strategies to improve their regenerative efficacy

P Faris, S Negri, A Perna, V Rosti, G Guerra… - International journal of …, 2020 - mdpi.com
Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory
diseases, which produce immense health and economic burdens worldwide. Currently …

Endothelial cells and organ function: applications and implications of understanding unique and reciprocal remodelling

M Reiterer, CM Branco - The FEBS Journal, 2020 - Wiley Online Library
The microvasculature is a heterogeneous, dynamic and versatile component of the systemic
circulation, with a unique ability to locally self‐regulate and to respond to organ demand and …

Pro-angiogenic effects of natural antioxidants extracted from mango leaf, olive leaf and red grape pomace over endothelial colony-forming cells

I Sánchez-Gomar, J Benítez-Camacho… - Antioxidants, 2022 - mdpi.com
Cardiovascular diseases remain the leading cause of death worldwide, mainly triggered by
the formation of atherosclerotic plaques that reduce blood flow. Angiogenic cell therapy …

[HTML][HTML] Human endothelial colony-forming cells

JM Melero-Martin - Cold Spring Harbor perspectives in medicine, 2022 - ncbi.nlm.nih.gov
Endothelial colony-forming cells (ECFCs) are progenitor cells that can give rise to colonies
of highly proliferative vascular endothelial cells (ECs) with clonal expansion and in vivo …

Stem Cells as a Regenerative Medicine Approach in Treatment of Microvascular Diabetic Complications

AS Poojari, S Wairkar, YA Kulkarni - Tissue and Cell, 2023 - Elsevier
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood glucose
and is associated with high morbidity and mortality among the diabetic population …

[HTML][HTML] miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

J Guduric-Fuchs, E Pedrini, J Lechner… - … Therapy-Nucleic Acids, 2021 - cell.com
Hypoxia modulates reparative angiogenesis, which is a tightly regulated pathophysiological
process. MicroRNAs (miRNAs) are important regulators of gene expression in hypoxia and …

Erythropoietin mimetic peptide (pHBSP) corrects endothelial dysfunction in a rat model of preeclampsia

M Korokin, V Gureev, O Gudyrev, I Golubev… - International Journal of …, 2020 - mdpi.com
Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic
pattern of events still require significant clarification, but it is now recognized that a large role …

[HTML][HTML] The Role of Erythropoietin in Metabolic Regulation

W Yin, CT Noguchi - Cells, 2025 - mdpi.com
Erythropoietin (EPO) is a key regulator of erythrocyte production, promoting erythroid
progenitor cell survival, division, and differentiation in the fetal liver and adult bone marrow …

Epigenetic regulation of endothelial cell function by nucleic acid methylation in cardiac homeostasis and disease

A Russell-Hallinan, CJ Watson, D O'Dwyer… - … Drugs and Therapy, 2021 - Springer
Pathological remodelling of the myocardium, including inflammation, fibrosis and
hypertrophy, in response to acute or chronic injury is central in the development and …

Advances in understanding the effects of erythropoietin on renal fibrosis

Y Zhang, X Zhu, X Huang, X Wei, D Zhao… - Frontiers in …, 2020 - frontiersin.org
Renal fibrosis is the common manifestation of the pathogenesis of end-stage renal disease
that results from different types of renal insult, and is a hallmark of chronic kidney disease …