MAPK/JNK signalling: a potential autophagy regulation pathway
YY Zhou, Y Li, WQ Jiang, LF Zhou - Bioscience reports, 2015 - portlandpress.com
Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization.
This pathway maintains nutrients levels for vital cellular functions during periods of …
This pathway maintains nutrients levels for vital cellular functions during periods of …
The ubiquitin system
A Hershko, A Ciechanover - Annual review of biochemistry, 1998 - annualreviews.org
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
Identification of regulatable mechanisms by which transcription factor NF-E2 p45-related
factor 2 (Nrf2) is repressed will allow strategies to be designed that counter drug resistance …
factor 2 (Nrf2) is repressed will allow strategies to be designed that counter drug resistance …
[HTML][HTML] The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction
MH Glickman, A Ciechanover - Physiological reviews, 2002 - journals.physiology.org
Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …
nucleic acids and the translation of the coded information. Protein degradation was a …
SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
Regulation of transcription factor Nrf2 (NF-E2-related factor 2) involves redox-sensitive
proteasomal degradation via the E3 ubiquitin ligase Keap1/Cul3. However, Nrf2 is …
proteasomal degradation via the E3 ubiquitin ligase Keap1/Cul3. However, Nrf2 is …
Mechanisms underlying ubiquitination
CM Pickart - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …
STATs and gene regulation
JE Darnell Jr - Science, 1997 - science.org
STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic
proteins that are activated to participate in gene control when cells encounter various …
proteins that are activated to participate in gene control when cells encounter various …
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying
enzymes and antioxidant stress proteins in response to electrophilic agents and oxidative …
enzymes and antioxidant stress proteins in response to electrophilic agents and oxidative …
AP-1 function and regulation
AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors
composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common …
composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common …
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
The RAD6 pathway is central to post-replicative DNA repair in eukaryotic cells; however, the
machinery and its regulation remain poorly understood. Two principal elements of this …
machinery and its regulation remain poorly understood. Two principal elements of this …