The mechanism of hyperglycemia-induced renal cell injury in diabetic nephropathy disease: an update

T Wu, L Ding, V Andoh, J Zhang, L Chen - Life, 2023 - mdpi.com
Diabetic Nephropathy (DN) is a serious complication of type I and II diabetes. It develops
from the initial microproteinuria to end-stage renal failure. The main initiator for DN is chronic …

Carbon dot therapeutic platforms: administration, distribution, metabolism, excretion, toxicity, and therapeutic potential

A Truskewycz, H Yin, N Halberg, DTH Lai, AS Ball… - Small, 2022 - Wiley Online Library
Ultrasmall nanoparticles are often grouped under the broad umbrella term of “nanoparticles”
when reported in the literature. However, for biomedical applications, their small sizes give …

Molecular mechanisms in early diabetic kidney disease: glomerular endothelial cell dysfunction

E Lassén, IS Daehn - International journal of molecular sciences, 2020 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with
prevalence increasing at an alarming rate worldwide and today, there are no known cures …

[HTML][HTML] Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis

S Jamaly, M Rakaee, R Abdi, GC Tsokos… - Autoimmunity reviews, 2021 - Elsevier
Kidney involvement confers significant morbidity and mortality in patients with systemic
lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse …

[HTML][HTML] Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease

A Petrazzuolo, G Sabiu, E Assi, A Maestroni… - Pharmacological …, 2023 - Elsevier
Diabetic kidney disease (DKD) is the first cause of end-stage kidney disease in patients with
diabetes and its prevalence is increasing worldwide. It encompasses histological alterations …

Recent advances in the pharmacological applications and liver toxicity of triptolide

D Cui, D Xu, S Yue, C Yan, W Liu, R Fu, W Ma… - Chemico-Biological …, 2023 - Elsevier
Triptolide is a predominant active component of Triptergium wilfordii Hook. F, which has
been used for the treatment of cancers and autoimmune diseases such as rheumatoid …

Targeting inflammation for the treatment of Diabetic Kidney Disease: a five-compartment mechanistic model

A Hofherr, J Williams, LM Gan, M Söderberg… - BMC nephrology, 2022 - Springer
Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide. Mortality
and morbidity associated with DKD are increasing with the global prevalence of type 2 …

[HTML][HTML] Therapeutic potential of pro-resolving mediators in diabetic kidney disease

T Vartak, C Godson, E Brennan - Advanced drug delivery reviews, 2021 - Elsevier
Renal microvascular disease associated with diabetes [Diabetic kidney disease-DKD] is the
leading cause of chronic kidney disease. In DKD, glomerular basement membrane …

A review of medicinal plants with renoprotective activity in diabetic nephropathy animal models

IMWA Putra, N Fakhrudin, A Nurrochmad, S Wahyuono - Life, 2023 - mdpi.com
Diabetic nephropathy (DN), also recognized as diabetic kidney disease, is a kidney
malfunction caused by diabetes mellitus. A possible contributing factor to the onset of DN is …

[HTML][HTML] Autophagy dysregulation in diabetic kidney disease: from pathophysiology to pharmacological interventions

CD Gonzalez, MP Carro Negueruela… - Cells, 2021 - mdpi.com
Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes
mellitus. Several factors are involved in its pathophysiology. At a cellular level, diabetic …