Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that
occurs during development and is essential for sha** embryos. Also implicated in cancer …

The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

This article proposes that biologically plausible theories of behavior can be constructed by
following a method of “phylogenetic refinement,” whereby they are progressively elaborated …

Vertebrates have greatly elaborated the basic chordate body plan and evolved highly
distinctive genomes that have been sculpted by two whole-genome duplications. Here we …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

The nervous system is a product of evolution. That is, it was constructed through a long
series of modifications, within the strong constraints of heredity, and continuously subjected …

Animal genomes are folded in topologically associating domains (TADs) that have been
linked to the regulation of the genes they contain by constraining regulatory interactions …

Morphological asymmetry is a common feature of animal body plans, from shell coiling in
snails to organ placement in humans. The signaling protein Nodal is key for determining this …

Dense multicilia in higher vertebrates are important for luminal flow and the removal of thick
mucus. To generate hundreds of basal bodies for multiciliogenesis, specialized terminally …

Lampreys and hagfish, which together are known as the cyclostomes or 'agnathans', are the
only surviving lineages of jawless fish. They diverged early in vertebrate evolution, before …