Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA
replication and replication-associated processes, including translesion synthesis, error-free …

Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism
as a component of the replication and repair machinery. This toroidal-shaped protein …

The crystal structure of the processivity factor required by eukaryotic DNA polymerase 6,
proliferating cell nuclear antigen (PCNA) from S. cerevisiae, has been determined at 2.3 A …

SUMMARY DNA repair and DNA damage tolerance machineries are crucial to overcome
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …

The eukaryotic replicative DNA polymerases (Pol α, δ and ɛ) and the major DNA
mutagenesis enzyme Pol ζ contain two conserved cysteine-rich metal-binding motifs (CysA …

Abstract Chromatin assembly factor 1 (CAF-1) is required for inheritance of epigenetically
determined chromosomal states in vivo and promotes assembly of chromatin during DNA …

The crystal structure of the p subunit (processivity factor) of DNA polymerase Ill holoenzyme
has been determined at 2.5 A resolution. A dimer of the p subunit (M,= 2 x 40.6 kd, 2 x 366 …

Replication of the two template strands at eukaryotic cell DNA replication forks is a highly
coordinated process that ensures accurate and efficient genome duplication. Biochemical …

CTF7 (c hromosome t ransmission f idelity) gene in budding yeast encodes an essential
protein that is required for high-fidelity chromosome transmission and contains regions of …

Complete enzymatic replication of DNA from the simian virus 40 origin has been
reconstituted with T antigen and highly purified cellular proteins. DNA polymerase-α/primase …