Dengue, caused by four closely related viruses, is a growing global public health concern,
with outbreaks capable of overwhelming health-care systems and disrupting economies …

Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …

The Zika pandemic sparked intense interest in whether immune interactions among dengue
virus serotypes 1 to 4 (DENV1 to-4) extend to the closely related Zika virus (ZIKV). We …

Background The ability to accurately predict early progression of dengue to severe disease
is crucial for patient triage and clinical management. Previous systematic reviews and meta …

There are an estimated 50 million infections per year with the dengue virus, which is
transmitted primarily by urban-adapted Aedes aegypti mosquitoes. This review summarizes …

Dengue is the second most common mosquito-borne disease affecting human beings. In
2009, WHO endorsed new guidelines that, for the first time, consider neurological …

Dengue is an acute illness caused by the positive-strand RNA dengue virus (DENV). There
are four genetically distinct DENVs (DENV-1–4) that cause disease in tropical and …

Dengue virus (DENV) infection can result in severe complications. However, the
understanding of the molecular correlates of severity is limited, partly due to difficulties in …

There has been considerable debate regarding the value of both the 1997 and 2009 World
Health Organization (WHO) dengue case classification criteria for its diagnosis and …