Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial
distribution and communicate through an elaborate system of vesiculo-tubular transport …

A functional genomic approach, based on systematic data gathering, was used to
characterize a family of proteins containing a tri partite m otif (TRIM). A total of 37 TRIM …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Formation of senile plaques containing the β-amyloid peptide (Aβ) derived from the amyloid
precursor protein (APP) is an invariant feature of Alzheimer's disease (AD). APP is cleaved …

The p53 tumour suppressor is a short-lived protein that is maintained at low levels in normal
cells by Mdm2-mediated ubiquitination and subsequent proteolysis,,. Stabilization of p53 is …

Oligodendrocytes secrete vesicles into the extracellular space, where they might play a role
in neuron–glia communication. These exosomes are small vesicles with a diameter of 50 …

Metastasis is the cause of death for patients with many types of cancer, but the process of
tumour cell dissemination is poorly understood. As primary tumours are three-dimensional …