Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …

A recent paper in this journal sought to counter evidence for the role of transport proteins in
effecting drug uptake into cells, and questions that transporters can recognize drug …

Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene
and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the …

Current efforts to reduce the global burden of malaria are threatened by the rapid spread
throughout Asia of Plasmodium falciparum resistance to artemisinin-based combination …

The emergence of Plasmodium falciparum parasite resistance to dihydroartemisinin+
piperaquine (PPQ) in Southeast Asia threatens plans to increase the global use of this first …

Membrane transport proteins, also known as transporters, control the movement of ions,
nutrients, metabolites, and waste products across the membranes of a cell and are central to …

Extrusion of chloroquine (CQ) from digestive vacuoles through the Plasmodium falciparum
CQ resistance transporter (PfCRT) is essential to establish CQ resistance of the malaria …

The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to
evaluate their in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought …

Coenzyme Q10 (CoQ10) deficiency currently represents the only treatable mitochondrial
disorder, however, little is known about how it may affect other organelles. The lysosome …

As it grows and replicates within the erythrocytes of its host the malaria parasite takes up
nutrients from the extracellular medium, exports metabolites and maintains a tight control …