Abstract The NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is
an immunological sensor that detects a wide range of microbial-and host-derived signals …

The concept of competitive endogenous RNA (ce RNA) was first proposed by Salmena and
colleagues. Evidence suggests that pseudogene RNA s can act as a 'sponge'through …

Advances in high-throughput and advanced technologies allow researchers to routinely
perform whole genome and proteome analysis. For this purpose, they need high-quality …

The inflammasome adapter ASC links activated inflammasome sensors to the effector
molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic …

Inflammasomes are assembled by innate immune sensors that cells employ to detect a
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …

Pseudogenes were initially regarded as “nonfunctional” genomic elements that did not have
protein-coding abilities due to several endogenous inactivating mutations. Although …

Canonical inflammasomes are innate immune protein scaffolds that enable the activation of
inflammatory caspase-1, and subsequently the processing and release of interleukin (IL)-1β …

Cell surface innate immune receptors can directly detect a variety of extracellular pathogens
to which cytoplasmic innate immune sensors are rarely exposed. Instead, within the …

Non-alcoholic steatohepatitis (NASH) is a prevalent chronic liver disease that lacks effective
treatment. In this study, the anti-NASH effects of four flavonoids (pinocembrin, galangin …

Inflammasomes are protein complexes that promote the maturation and release of pro‐
inflammatory cytokines and danger signals as well as pyroptosis in response to infections …