Towards organoid culture without Matrigel
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …
function in miniature—are of growing interest in developmental biology and medicine …
Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …
attention in both basic and translational biomedical studies. Although the classical hydrogels …
Advances in engineering hydrogels
BACKGROUND Hydrogels are formed through the cross-linking of hydrophilic polymer
chains within an aqueous microenvironment. The gelation can be achieved through a …
chains within an aqueous microenvironment. The gelation can be achieved through a …
Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Advancing biomaterials of human origin for tissue engineering
FM Chen, X Liu - Progress in polymer science, 2016 - Elsevier
Biomaterials have played an increasingly prominent role in the success of biomedical
devices and in the development of tissue engineering, which seeks to unlock the …
devices and in the development of tissue engineering, which seeks to unlock the …
3D bioprinting of heterogeneous constructs providing tissue‐specific microenvironment based on host–guest modulated dynamic hydrogel bioink for osteochondral …
Abstract 3D bioprinting is a promising strategy to develop heterogeneous constructs that
mimic osteochondral tissue. However, conventional bioprinted hydrogels suffer from …
mimic osteochondral tissue. However, conventional bioprinted hydrogels suffer from …
[HTML][HTML] Extracellular matrix: a dynamic microenvironment for stem cell niche
F Gattazzo, A Urciuolo, P Bonaldo - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …
characterized by biophysical, mechanical and biochemical properties specific for each …
25th anniversary article: Rational design and applications of hydrogels in regenerative medicine
Hydrogels are hydrophilic polymer‐based materials with high water content and physical
characteristics that resemble the native extracellular matrix. Because of their remarkable …
characteristics that resemble the native extracellular matrix. Because of their remarkable …
Materials as stem cell regulators
The stem cell/material interface is a complex, dynamic microenvironment in which the cell
and the material cooperatively dictate one another's fate: the cell by remodelling its …
and the material cooperatively dictate one another's fate: the cell by remodelling its …
Multileveled Hierarchical Hydrogel with Continuous Biophysical and Biochemical Gradients for Enhanced Repair of Full‐Thickness Osteochondral Defect
The repair of hierarchical osteochondral defect requires sophisticated gradient
reestablishment; however, few strategies for continuous gradient casting consider the …
reestablishment; however, few strategies for continuous gradient casting consider the …