A majority of mammalian genes exhibit daily fluctuations in expression levels, making
circadian expression rhythms the largest known regulatory network in normal physiology …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

Immune parameters change with time of day and disruption of circadian rhythms has been
linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow …

The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …

The mammalian circadian clock relies on the master genes CLOCK and BMAL1 to drive
rhythmic gene expression and regulate biological functions under circadian control. Here we …

A vast network of cellular circadian clocks regulates 24‐hour rhythms of behavior and
physiology in mammals. Complex environments are characterized by multiple, and often …

Transcriptional feedback loops are central to the architecture of eukaryotic circadian clocks.
Models of the Arabidopsis thaliana circadian clock have emphasized transcriptional …

A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …

Daily interactions between the hypothalamic circadian clock at the suprachiasmatic nucleus
(SCN) and peripheral circadian oscillators regulate physiology and metabolism to set …

Abstract Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the
link between the two processes in relation to SIRT1 function is not clear. Using Sirt1 …