Different mechanisms mediate the toxicity of RNA. Genomic retroviral mRNA hijacks infected
host cell factors to enable virus replication. The viral genomic RNA of the human …

The diversity in the biological response of 4-thiazolidinones has attracted the attention of
many researchers to explore this framework for its potential. It is, therefore, of prime …

▪ Abstract Viral envelope glycoproteins promote viral infection by mediating the fusion of the
viral membrane with the host-cell membrane. Structural and biochemical studies of two viral …

In general terms, the replication cycle of lentiviruses, including HIV-1, closely resembles that
of other retroviruses. 1 There are, however, a number of unique aspects of HIV replication; …

The major structural components of HIV-1 are encoded as a single polyprotein, Gag, which
is sufficient for virus particle assembly. Initially, Gag forms an approximately spherical shell …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

The human immunodeficiency virus type 1 initially assembles and buds as an immature
particle that is organized by the viral Gag polyprotein. Gag is then proteolyzed to produce …

The medical properties of naturally occurring compounds such as chromones, flavonoids
and coumarins have been well known for many years. However, the discovery that their …

Currently, the understanding of the relationships between function, amino acid sequence,
and protein structure continues to represent one of the major challenges of the modern …

Publisher Summary This chapter focuses on recent biochemical and biophysical studies that
examine the nucleic acid chaperone function of HIV‐1 nucleocapsid protein (NC) and its …